Who can do what it takes?

Carl Heneghan

Tuesday, December 14 2010 at 7:30PM

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56 Walton Street,
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Carl Heneghan

What's the talk about?

Carl Heneghan Director of the Centre for Evidence-Based Medicine, and trusttheevidence blogger will discuss why a number of high-profile drugs have been later withdrawn despite having once cleared regulatory hurdles.

In September , Avandia, the top-selling diabetes drug in the world in 2006, made by British company GSK was withdrawn from the market after regulators agreed with independent scientists that the medicine carried an unacceptably high risk of causing heart attacks. He will be discussing his recent work which raises serious concerns about the lack of evidence supporting the safety and effectiveness of the blockbuster anti-flu drug Tamiflu.

Backed by the Cochrane Library, the BMJ this talk will hopefully coincide with a controversial publication: Ensuring safe and effective evidence for drugs -- who can do what it takes? Authored by Tom Jefferson, Peter Doshi, Matthew Thompson, and Carl J Heneghan.

This is what [Tom Clarke channel 4](
news had to say: During the swine flu pandemic last year courses of Tamiflu were handed
out to anyone with symptoms calling the government's National Pandemic Flu Service. In the first two weeks of the pandemic, 500,000 courses of the drug were prescribed nationwide. The government spent more than £500 million stockpiling antiviral drugs like Tamiflu in preparation for a pandemic.

An international group of public health specialists found, during a routine review of flu drugs, that there was insufficient evidence in the public domain to account for Tamiflu's effectiveness as a pandemic flu drug. They particularly criticised a key paper used to justify Tamiflu's use during pandemics to international regulatory authorities.


Carl Heneghan is a Clinical Lecturer in the Department of Primary Health Care, University of Oxford, Director of the Centre of Evidence-Based Medicine and a General Practitioner. He has had an association with the Centre for Evidence-Based Medicine since 1995. He currently is a Walport Clinical Lecturer having previously held a NCCRD Research Development Fellowship.